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10.1111/cns.13610 ↑ Truscott RJW, Mizdrak J, Friedrich MG, et al.: Is protein methylation in the human lens a result of non-enzymatic methylation by S-adenosylmethionine

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This means the problem is not only “not enough fuel,” but also “broken machinery.” GSH (Glutathione) depletion links directly to vascular dysfunction, neuropathy, nephropathy, and retinopathy