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131 In neutrophils, SIRT1 inhibits IKKβ acetylation, stabilizing IκBα and preventing NF-κB nuclear translocation and downstream expression of chemokines such as CXCL1 and IL-8, reducing neutrophil recruitment

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Telaglenastat plus everolimus in advanced renal cell carcinoma: a randomized, double-blinded, placebo-controlled, phase II ENTRATA trial