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Doses as high as 2 mg (2,000 μg) daily by mouth or 1 mg monthly by intramuscular (IM) injection have been used to treat pernicious anemia without significant side effects (136)

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Possible candidate of the BDNF/TrkB dysfunctions is the intracellular transport process of “synthesized” BDNF-containing vesicles for preparing secretion to surrounding cells and “received” BDNF-TrkB complex to send signals to the cell body