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Keywords: melanin index, melanogenesis, oxidized glutathione, reduced glutathione, skin whitening, topical Introduction Skin aging is a complex biological phenomenon consisting of two independent clinically and biologically distinct processes, namely “intrinsic aging” and “extrinsic aging.” 1 , 2 Extrinsic aging (including “photoaging”) is the result of exposure to outdoor elements, primarily ultraviolet (UV) irradiation