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Bilirubin may also inhibit other diseases through its inhibitory effect on oxidative stress and thus inhibit tumors, for example, the occurrence of metabolic syndrome is closely related to oxidative stress (62), and some studies have also shown a negative relationship between the level of human serum total bilirubin and the incidence of metabolic syndrome (63–65), which in turn is positively correlated with the occurrence of many cancers, e.g., cancers of lung and colorectal (66–68), so bilirubin may inhibit the development of related cancers in this way

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Comorbidity in older surgical cancer patients: influence on patient care and outcome