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Witschi and colleagues (1992) gave seven healthy volunteers a single oral dose of 0.15 mmol/kg, roughly 3 g, and measured plasma glutathione, cysteine and glutamate over 270 minutes

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It was first licensed for the treatment of type 2 diabetes but has since been approved for use in weight management in adult patients who are obese or overweight with comorbidities including hypertension, obstructive sleep apnoea or high cholesterol