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Introduction The blood–brain barrier (BBB) is a dynamic physiological structure that constitutes an interface between the vasculature system and the neural tissues, regulating diverse processes such as cerebral blood flow and angiogenesis, neuronal development, and synaptic activity (1)

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However, the expression of xCT can be induced in many types of cells in response to stress conditions such as oxidative stress and hyperoxia, which are likely mediated by transcriptional regulatory factors Nrf2 and ATF4 [51,52]