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Anti-ferroptotic genes, including SLC7A11 and HO-1, which support cellular survival, have their transcription activated by Nrf2

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scar tissue formation at the injury site Anti-inflammatory — down-regulates NF-κB signaling, one of the key inflammatory pathways active in disc herniations Works in synergy with BPC-157 — while BPC-157 creates the growth signals, TB-500 provides the cellular migration framework to execute the repair Protocol: Loading phase: 2.5mg–5mg/week subcutaneous injection for 4–6 weeks Maintenance: 1.25–2.5mg/week ongoing Frequency: Single weekly injection or split into two 1.25mg injections across the week (both approaches work) The Synergy: Why Run Both Together BPC-157 and TB-500 work through different but complementary mechanisms