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As expected of neutral antagonists, 6 β -naltrexol (Lam et al., 2011) and d-Phe-Cys-Tyr-d-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) (Walwyn et al., 2007) antagonized the inverse agonist actions of naloxone and naltrexone

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Newer evidence points to additional cellular and physiological effects caused by lack of cellular oxidants and accumulation of excess reducing equivalents, including changes in protein disulfide bond formation, diminished mitochondrial function, and decreased cellular metabolism