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The role of dietary antioxidants in type 2 diabetes and neurodegenerative disorders: An assessment of the benefit profile - PMC

The reasons for these changes, apart from excess ROS leading to increased GSH depletion in cardiomyocytes, are disturbances in the anabolic process of GSH, causing a further decrease in intracellular GSH content

NAD/Resveratrol

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This is due to enhanced sumoylation of Nrf2 and MafG by SUMO-1 in the quiescent state, which facilitated heterodimerization and binding to ARE [174]