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Vitamin B12 Deficiency: A Fact Sheet on Signs, Treatment and Benefits

doi: 10.1016/j.jid.2025.06.1595

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The factor responsible turned out to be a small copper-binding tripeptide whose endogenous concentration declines with age — from roughly 200 ng/mL at age 20 to 80 ng/mL at age 60. The 50-year research arc that followed makes GHK-Cu one of the most thoroughly characterized small peptides in the literature