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Gastrointestinal Histology As in previous studies [12,13,14,15,16,20,22,23,24], we used a histologic scoring scale adapted from Chui and coworkers [52] for the intestinal tissue damage, scoring 0–5 (normal to severe) in three categories (mucosal injury, inflammation, and hyperemia/hemorrhage) for a total score of 0 to 15, as described by Lane and coworkers [53]