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To synthesize the amino acid cysteine, the body requires adequate levels of folate, vitamin B6, and vitamin B12

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Reduced GPX4 expression in turn means that this protective system is reduced and thus enhancing susceptibility of chondrocytes to oxidative stress via MAPK/NF-κB signaling ( − inhibition dependent and driving a process that culminates in the fat-induced final lethal step of the lipid peroxidation and GPX4 play a prominent protective role in it