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What makes them noteworthy is the novelty of their targets: Dihexa works through the hepatocyte growth factor (HGF) / c-Met receptor system, while PE-22-28 blocks TREK-1 two-pore domain potassium channels

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Because the circuits are partly distinct, the effects tend to add rather than overlap, and the combination can deliver more total appetite suppression at amounts that neither compound would need to reach alone