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Plumbagin increased NAD(P)H quinone dehydrogenase 1 (NQO1) activity and decreased xCT expression, resulting in NQO1-dependent glioma cell death

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Strategies to incorporate sulfur atom into biomolecules involve biosyntheses of iron sulfur clusters, cofactors such as thiamin, molybdopterin, biotin and lipoic acid, and the thio-modification of tRNA via enzymatically generated persulfide species at enzyme active sites