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Some studies suggested phosphatidylinositol 3-kinase as the key enzyme involved in the regulation of glucose uptake into cells by GH (175, 181, 182) while others found this mechanism to be of low significance as these experiments have not been replicated in humans (176, 177)

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The researchers searched for the RCTs from a number of databases, including PubMed, EMBASE, Cochrane, and CINAHL