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People with Absorption Issues Several conditions can impair B12 absorption: Pernicious anaemia — An autoimmune condition that’s the most common cause of severe B12 deficiency in the UK Crohn’s disease or coeliac disease Previous gastric surgery — Including gastric bypass Chronic use of certain medications — Including proton pump inhibitors (PPIs), metformin, and some anti-seizure medications Others at Risk Pregnant and breastfeeding women (who have increased B12 requirements) Heavy alcohol consumers Those with chronic inflammation affecting gut health People taking certain oral contraceptives B12 Deficiency in the UK: How Common Is It

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Key benefits Why people compare it 1 FDA-approved as Egrifta for visceral adipose tissue reduction in lipodystrophy 2 15-18% VAT reduction demonstrated in two Phase 3 trials (N=816) 3 Improved triglycerides and waist circumference in key clinical data 4 Extended half-life (26-38 min) vs sermorelin due to trans-3-hexenoic acid modification 5 Improved verbal memory and executive function in older adults (Neurology study, p=0.03) 6 Physiological GH stimulation with intact pituitary negative feedback 7 Demonstrated 32% hepatic fat reduction in 12-month NAFLD trial 8 Well-characterized safety profile through FDA approval and post-marketing surveillance Deep research About Tesamorelin Tesamorelin is a synthetic analog of human growth hormone-releasing hormone (GHRH) consisting of all 44 amino acids of native GHRH with a trans-3-hexenoic acid moiety conjugated to the tyrosine residue at position 1 via a carbamate linker