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It also includes CD38, a membrane‐bound enzyme that depletes NAD+ while regulating calcium signaling and NAMPTs, rate‐limiting enzymes in the NAD salvage pathway, essential for maintaining NAD+ levels, and NAD kinase that converts NAD+ into NADP+, and used in anabolic reactions (Campagna and Vignini 2023)

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High doses of Thiamine are reported to help calm nervous or over excitable horses