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The induced oxidative stress because of the high accumulation of ROS can be mitigated through a complex series of ROS-scavenging or -detoxifying systems such as enzymatic and/or non-enzymatic antioxidants

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It has become clear that symptoms of COPD are not only of the respiratory system but of many other organs and systems combined, including the musculoskeletal system (5), circulatory system, cardiac system (6), immune system (7), bone metabolism (8), and others (9)