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Supplementary material The Supplementary Material for this article can be found online at: Glossary AD Alzheimer’s disease AI artificial intelligence ApoE apolipoprotein E Ascl1 Achaete-Scute bHLH factor 1 ASD Autism Spectrum Disorder BBB blood brain barrier BDNF brain-derived neurotrophic factor BrdU 5-bromo-2′-deoxyuridine CAS core aging signature Cxcr4 CXC motif chemokine receptor 4 DCX Doublecortin DG dentate gyrus E embryonic day EED embryonic ectoderm development ETNPPL ethanol phosphate phospholipase FACS fluorescence-activated cell sorting GC granule cells GFAP glial fibrillary acidic protein GFP green fluorescent protein GO terms Gene Ontology terms Hopx Homeodomain-only protein IFN-gamma Interferon-gamma imGC immature GC IMPA1 inositol monophosphatase 1 IP intermediate progenitor IPs intermediate progenitors iPSC induced pluripotent stem cell KA kainic acid KDM4C histone lysine demethylase 4C L-RUN, H-RUN low or high runners lncRNAs long noncoding RNAs LPA1 lysophosphatidic acid receptor 1 LRRK2 leucine-rich repeat kinase 2 Mbd1 methyl-CpG-binding domain 1 MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine MTLE mesial temporal lobe epilepsy Nfix nuclear factor one X NPCs neural progenitor cells NSC neural stem cell O-GlcNAc O-linked β-N-acetylglucosamine P postnatal day PRL Prolactin Prox1 Prospero homeobox 1 REST Repressor element 1-silencing transcription factor RGL radial glial like sc/snRNA-seq single-cell/single-nucleus RNA Sequencing SGZ subgranular zone SHR spontaneously hypertensive rats SI social isolation Sirt1 Sirtuin 1 Snca alpha-synuclein Sox2 Sex determining region Y-Box 2 SVZ subventricular zone TAPC transiently amplifying progenitor cell TBI traumatic brain injury VPA valproic acid

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doi: 10.1016/j.virusres.2014.09.016