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Acne has many causes, including: Build-up of bacteria Overproduction of sebum, which clogs pores Hormonal imbalances Gut imbalances Genetics Smoking Stress Dietary triggers like dairy, sugar, and highly processed foods Comedogenic skin care products Skin barrier damage Also associated with the development of acne is oxidative stress, which doesn’t occur only after breakouts rear their head

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Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors