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Materials and methods Study approval and registration The investigator-initiated GSH-MAP study (ClinicalTrials.gov Identifier: NCT 03596125) was conducted in the Department of Obstetrics (2018-2021), funded by the University-Hospital of Nantes, and approved by the medical ethical committee ( CPP-EST I , N°2017/65), besides the National Agency for the Safety of Medicines and Health Products (N° EudraCT 2017-003999-31)