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NNMT’s role is to transfer a methyl group to nicotinamide (vitamin B3), creating 1-methylnicotinamide — a reaction that consumes cellular methyl donors and depletes nicotinamide adenine dinucleotide (NAD⁺) stores

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Additionally, it was confirmed in a mouse model of asthma that the application of exogenous hBD-2 prevents key symptoms of asthma, such as BALF inflammatory cell influx, cytokine production and AHR [259,260]