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Red flags requiring medical evaluation include progressive weakness, bowel or bladder dysfunction, unexplained weight loss, fever, or worsening symptoms despite treatment

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57 Positive effects of B12 on homocysteine levels have also been observed in other patient populations, including healthy adults, 46 vegetarian women, 58 generally healthy women, 59 older adults with elevated MMA and homocysteine, 37 and patients with type 2 diabetes mellitus