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Although NOX2 has been shown to enhance the pathogenesis in IAV infection through endosomal NOX2 oxidase-dependent ROS production, NOX4 oxidase exerts a protective effect against IAV infection 72

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The Sugimoto 1995 study documented that copper ions inhibit type 1 5-alpha reductase by up to 90% in vitro, with 50% inhibition at 0.12 mcg copper/mL