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Neuron 17:1157–1172 [DOI] [PubMed] [Google Scholar] El-Husseini AE, Schnell E, Chetkovich DM, Nicoll RA, Bredt DS

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In conclusion, the study robustly demonstrated that FOXO4-DRI selectively eliminates senescent Leydig cells, reduces detrimental SASP factor secretion, improves the testicular microenvironment, and ultimately enhances sperm quality and spermatogenesis in aged mice, positioning it as a promising therapeutic candidate for age-related male infertility [2]