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Second, the increase in HPA-axis sensitivity and reactivity occurring during adolescence may promote an increase in metabolic demand and the generation of ROS, leading to a compensatory increase in the activity of detoxifying enzymes in females [25]

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Relevant to PASC, metabolomic analyses of plasma samples from individuals convalescing from COVID-19 have identified taurine as one of the top upregulated metabolites six months post-infection [22–24]