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Since humans are not able to synthesize vitamins in B complex on their own and these vitamins are easily excreted from the body through urine, their regular intake is essential to maintain energy production, DNA/RNA synthesis/repair, genomic and non-genomic methylation as well as synthesis of numerous neurochemicals and signalling molecules

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Vitamin B12 supplementation supports energy levels that can dip during caloric restriction, and some compounding pharmacies offer tirzepatide pre-mixed with B12