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Pm-ME (0–400 μg mL −1 ) significantly reduced tyrosinase activity at concentrations above 200 μg mL −1

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Capsule count:60 Capsules

Given that NNMT has been reported to be a primary metabolic enzyme[36] and a major clearance pathway for intracellular NA,[15] it is likely that these small molecules are directly and selectively inhibiting the conversion of NA to 1-MNA