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Signal bay Minimal four
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04 — Broadcast

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In high-glucose–challenged retinal pigment epithelial cells, PCs activate the p53/mTOR autophagy pathway, lowering apoptosis-related factors (e.g., Bax, Caspase-3, LC3-II/LC3-I, and phosphorylated p53) and elevating the levels of survival proteins (Bcl-2, p62, and phosphorylated mTOR) (Li et al., 2022)

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