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While a 2008 study 4 suggests that low vitamin D levels contribute to a worsening of Parkinson’s symptoms, a 2015 study 5 suggests that thiamine, also known as vitamin B1, levels may also be a factor

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Better still, if you know you will be on 0.25mg for four weeks and then 0.5mg for the next four weeks, you can plan your reconstitution date so that the 28-day window covers both titration steps