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Additionally, cidofovir is widely used for managing recurrent respiratory papillomatosis (RRP), where it interferes with viral DNA replication, increasing relapse-free times and reducing the need for surgeries

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127 During infection, a spatiotemporally coordinated mechanism enhances this effect: Rab32 recruits mitochondrial IRG1 to Salmonella-containing vacuoles, enabling localized itaconate delivery, while TFEB promotes IRG1 expression and Rab32-BLOC3-dependent lysosomal biogenesis, amplifying bactericidal activity