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The significantly reduced expression of HMGB1 in intracellular 4T1 cells treated with free OLE and PEG-T ECM -NS/OLE pretreated at pH 6.8 with 100 µM H 2 O 2 indicated that considerable amount of HMGB1 was released to extracellular environment

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8 A 2005 review framed Tβ4 memorably as an actin-sequestering protein that “moonlights” to repair injured tissues when released after injury