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2025 systematic review notes the most-cited human exposure as a small open-label knee-pain case series in which 7 of 12 subjects reported pain relief lasting more than 6 months after one intra-articular BPC-157 injection

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The compound shows high enzymatic selectivity, preserves lean mass, and engages longevity-related pathways (e.g., SIRT1), but remains a non–FDA-approved research substance that is WADA-banned and should be used under medical guidance