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Saturated free fatty acids and gut-derived LPS can activate them through the TLR4-MD2 complex, triggering ROS production and the secretion of proinflammatory cytokines such as IL-1β and TNF-α (47)

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Diagnosis typically involves blood tests including full blood count (showing macrocytosis), anti-intrinsic factor antibodies (which are specific for pernicious anaemia), and sometimes anti-parietal cell antibodies