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Pharmacological inhibition of D1-like receptors using SCH23390, or knockout of Drd5 specifically on DCs reduced inflammation in an EAE model (Prado et al., 2018), antagonizing D1-like receptors also suppresses T h 17 and neutrophilic lung inflammation signaling (Nakagome et al., 2011), both suggesting that D1-like receptor signaling drives inflammation

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Jun 21 2023;24(13)doi:10.3390/ijms241310443