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for instance, Cryptococcus neoformans infection induces excessive mitophagy, blunting immune cell activation and cytokine production ( 4.5 Fungal-induced mitochondrial signaling and innate immune activation Mitochondria serve as signaling platforms for innate immune pathways such as MAVS-dependent antiviral signaling, the NLRP3 inflammasome, and cGAS-STING

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PTP1B is a negative regulator of the leptin and insulin signaling pathways, so it has emerged as an attractive novel target for the treatment of both type 2 diabetes and obesity [51]