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(2021) employed tandem mass tag proteomics (TMT) and mass spectrometry (MS) to analyze PBMC, identifying differential expression of proteins regulated by the liver X receptor-retinoid X receptor (LXR/RXR) pathway, which modulates lipid metabolism and inflammation, potentially influencing the expression of pro-inflammatory cytokine genes (Schulman, 2017)

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GLP-1 receptor activation slows gastric emptying, which reduces the rate of postprandial glucose absorption and attenuates the postprandial glucose excursion — an effect that becomes measurable within the first weeks of the escalation phase even at the 2mg starting dose