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The response of plant defense system to stress varies with the times, duration of contact and stress severity, type of organ or tissue and developmental stage 10,11

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However, it's important to contextualize this assessment within the limitations of the available evidence: most safety data comes from relatively small studies, often of short-to-moderate duration, conducted primarily in the Soviet Union, Russia, and Eastern Europe where methodological standards and reporting practices have sometimes differed from Western pharmaceutical trial requirements