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MOTS-C is the closest comparison of those, since it also acts on cellular energy metabolism, but MOTS-C is a mitochondrial peptide working through AMPK rather than a small molecule sparing a methyl donor

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Although it cannot yet be determined whether vitamin B 12 deficiency plays a causal role in depression, it may be beneficial to screen for vitamin B 12 deficiency in older individuals as part of a medical evaluation for depression