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EXOs have been found to co-precipitate with other cellular components, including other extracellular vesicles, protein clumps, and even extremely abundant proteins, in a variety of biofluids such as plasma and serum
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It is a neutral, mildly lipophilic molecule with no free ionisable groups at physiological pH, which is the structural reason vendors ship it with DMSO instructions rather than plain bacteriostatic water — covered in the dihexa reconstitution guide