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Endogenous PTHrP plays an important role in fracture healing as demonstrated in an PTHrP haplo-insufficiency model where reduced cartilaginous and bony callus formation was noted together with reduced endochondral and osteoblastic bone formation [229]

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A dysregulation between the enhanced mitochondria-related processes of apoptosis and the inhibited autophagy leads to the accumulation of toxic products in the brains of individuals with ASD