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We first elucidate the intricate pathophysiological mechanisms linking hyperuricemia, monosodium urate (MSU) crystal deposition, NLRP3 inflammasome activation, and chronic inflammation

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Since system X c − functions as a primary source of cysteine for GSH biosynthesis, these erastin-resistant cells might have developed an alternative source to provide cysteine, compensating the shortage of cystine influx resulting from system X c − blockage