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Recently, Lip-2, an analog of Lip-1, showed improved pharmacokinetics and greater effectiveness in treating lupus nephritis both in vitro and in vivo ( Phenothiazines (PTZs) and phenoxazines (PNXs), as tricyclic aromatic amine-based ROS scavengers, exhibit potent antiferroptotic activity and favorable pharmacokinetics (Shah et al., 2017)

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Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-alpha and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice