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The most important intracellular antioxidant enzymes are glutathione peroxidase (GPX), catalase, and superoxide dismutase (SOD) ( When compared to liver antioxidant levels, pancreatic islets contain 1% catalase, 29% SOD1, and 2% GPX1 activity, leaving the beta-cells with considerably low antioxidant protection and vulnerable to oxidative stress

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